Hasko Lab
Principal Investigator
The research of the Hasko Lab is centered on the role of P1 (adenosine) and P2 (ATP) purinergic receptors in regulating inflammation and organ function in sepsis. The lab uses state-of-the-art techniques, such as the "cre-lox” technology to delineate the role purinergic receptors on the various cell types that are involved in orchestrating the host's inflammatory response to sepsis. In mechanistic in vitro studies, the Hasko Lab aims to clarify the molecular processes underpinning the purinergic regulation of inflammation, and we are especially interested in cells of the innate immune system, such as macrophages and innate lymphoid cells. In addition, we are interested in how purinergic receptors regulate inflammation, organ injury, and immunity to intestinal worms.