HT Lee Lab

Our research focuses on the pathomechanisms of perioperative acute kidney injury and translational approaches to attenuate this injury. The laboratory is focusing on the role of ischemic preconditioning, adenosine receptors, sphingosine products, volatile anesthetics and local anesthetics in attenuating acute kidney injury in vivo as well as in vitro. The models used to induce acute kidney injury in vivo include renal ischemia reperfusion, cecal ligation and puncture-induced sepsis, and myoglobinuria rhabdomyolysis model. Recently, a model of acute kidney injury in the setting of acute liver failure (hepatorenal syndrome) has been developed and multiple treatment modalities to treat this critical syndrome are being investigated. We use multiple molecular and biochemical approaches as well as in vivo techniques to better understand both the injurious and protective signaling pathways involved in the injury.