Hua Lab

Principal Investigator

Our research applies mixed-method approaches to improve palliative and end-of-life care. We utilize population-level analyses of outcomes combined with qualitative techniques to create a holistic view of practice patterns in palliative and critical care. This approach allows us to inform best practices for palliative and end-of-life care delivery, with an overarching goal of improving outcomes for patients with serious illness.

The intersection between palliative care and critical care is a prime focus of our research lab. As more critically ill patients choose quality of life as opposed to quantity of life, there is a growing awareness that high-intensity care, particularly at the end of life, may not be consistent with patients’ goals and values. Thus, we aim to better quantify how palliative care impacts the intensity of treatment in critically ill patients.

Additionally, we are researching how heterogeneity in how specialist palliative care is implemented across different hospitals may result in differences in the quality and impact of palliative care across institutions. Our NIH-funded R37 grant allows us to better understand what ideal operating conditions are needed by palliative care teams to ensure high-quality care nationwide. With this, our goal is to learn how variability in palliative care programs affects patient outcomes for patients with metastatic cancer, as well as further understand how palliative care delivery may impact all patients with serious illnesses.

Lab Members

Select Publications

  • Lackraj D, Kavalieratos D, Murali KP, Lu Y, Hua M. Implementation of Specialist Palliative Care and Outcomes for Hospitalized Patients with Dementia. J Am Geriatr Soc. 2021 May;69(5):1199-1207. doi: 10.1111/jgs.17032. Epub 2021 Feb 1. PMID: 33523466; PMCID: PMC8202070.

  • Lackraj D, Kavalieratos D, Murali KP, Lu Y, Hua M. Implementation of Specialist Palliative Care and Outcomes for Hospitalized Patients with Dementia. J Am Geriatr Soc. 2021 May;69(5):1199-1207. doi: 10.1111/jgs.17032. Epub 2021 Feb 1. PMID: 33523466; PMCID: PMC8202070.

  • Hua M, Lu Y, Ma X, Morrison RS, Li G, Wunsch H. Association Between the Implementation of Hospital-Based Palliative Care and Use of Intensive Care During Terminal Hospitalizations. JAMA Netw Open. 2020 Jan 3;3(1):e1918675. doi: 10.1001/jamanetworkopen.2019.18675. PMID: 31913493; PMCID: PMC6991248.

  • Hua M, Ma X, Morrison RS, Li G, Wunsch H. Association between the Availability of Hospital-based Palliative Care and Treatment Intensity for Critically Ill Patients. Ann Am Thorac Soc. 2018 Sep;15(9):1067-1074. doi: 10.1513/AnnalsATS.201711-872OC. PMID: 29812967; PMCID: PMC6137683.

  • Hua M, Halpern SD, Gabler NB, Wunsch H. Effect of ICU strain on timing of limitations in life-sustaining therapy and on death. Intensive Care Med. 2016 Jun;42(6):987-94. doi: 10.1007/s00134-016-4240-8. Epub 2016 Feb 9. PMID: 26862018; PMCID: PMC4846491.

  • Hua MS, Li G, Blinderman CD, Wunsch H. Estimates of the need for palliative care consultation across United States intensive care units using a trigger-based model. Am J Respir Crit Care Med. 2014 Feb 15;189(4):428-36. doi: 10.1164/rccm.201307-1229OC. PMID: 24261961; PMCID: PMC3977718.

  • Hua M, Scales DC, Cooper Z, Pinto R, Moitra V, Wunsch H. Impact of Public Reporting of 30-day Mortality on Timing of Death after Coronary Artery Bypass Graft Surgery. Anesthesiology. 2017 Dec;127(6):953-960.

  • Hua M, Gong MN, Miltiades A, Wunsch H. Outcomes After Rehospitalization at the Same Hospital or a Different Hospital Following Critical Illness. Am J Respir Crit Care Med. 2017 Jun 1;195(11):1486-1493.